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Director

Dr. Abdul Rouf Mir

Director, Center for Research and Policy Studies (CRPS),
Baramulla, Jammu and Kashmir

Education

Ph.D. Biochemistry

Jawaharlal Nehru Medical College, Aligarh Muslim University, India

M. Sc. Biotechnology

University of Madras, India

B. Sc. in Chemistry and Biology

University of Kashmir, India

Publications

1. Mir AR, Habib S, Moinuddin. Recent Advances in Histone Glycation: Emerging role in Diabetes and Cancer.
Glycobiology (Oxford). 2020. DOI: 10.1093/glycol/cwab011

2. Rizwee MM, Abidi M, Habib S, Mir AR, Ali A, Moinuddin. Characterization of glyoxal modified LDL: Role in the generation of circulating autoantibodies in type 2 diabetes mellitus and coronary artery disease.
Current Drug Targets 2020. DOI: 10.2174/1389450122666210114123959.

3. Glycoxidation of LDL Generates Cytotoxic Adducts and Elicits Humoral Response in Type 2 Diabetes Mellitus. Abidi M, Mir AR, Khan F, Ali A, Uddin M.
Glycobiology (Oxford). 2020 Aug 8:cwaa077. doi: 10.1093/glycob/cwaa077

4. Preferential recognition of epitopes on peroxynitrite-modified alpha-2-macroglobulin by circulating autoantibodies in rheumatoid arthritis patients.
Malik HI, Mir AR, Abidi M, Habib S, Khan FH, Moinuddin.
J Biomol Struct Dyn. 2020 Apr;38(7):1984-1994. DOI: 10.1080/07391102.2019.1623073.

5. Methylglyoxal modified IgG generates an autoimmune response in rheumatoid arthritis. Islam S, Mir AR, Abidi M, Talha M, Zafar A, Habib S, Moinuddin.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):15-23. doi: 10.1016/j.ijbiomac.2018.06.040.

6. Unsaturated aldehyde, 4-hydroxynonenal (HNE) alters the structural integrity of HSA with consequences in the immuno-pathology of rheumatoid arthritis.
Khan F, Moinuddin, Mir AR, Islam S, Abidi M, Husain MA, Khan RH.
Int J Biol Macromol. 2018 Jun;112:306-314. doi: 10.1016/j.ijbiomac.2018.01.188.

7. Structural and immunological characterization of hydroxyl radical modified human IgG: Clinical correlation in rheumatoid arthritis.
Islam S, Mir AR, Arfat MY, Khan F, Zaman M, Ali A, Moinuddin.
Spectrochim Acta A Mol Biomol Spectrosc. 2018 Apr 5;194:194-201. DOI:
10.1016/j.saa.2018.01.026.

8. Glycation, oxidation, and glycoxidation of IgG: a biophysical, biochemical, immunological, and hematological study.
Islam S, Moinuddin, Mir AR, Raghav A, Habib S, Alam K, Ali A.
J Biomol Struct Dyn. 2018 Aug;36(10):2637-2653. DOI: 10.1080/07391102.2017.1365770.

9. Studies on glycoxidatively modified human IgG: Implications in immuno-pathology of type 2 diabetes mellitus.
Islam S, Moinuddin, Mir AR, Arfat MY, Alam K, Ali A.
Int J Biol Macromol. 2017 Nov;104(Pt A):19-29. doi: 10.1016/j.ijbiomac.2017.05.190.

10. Neo-Epitopes Generated on Hydroxyl Radical Modified GlycatedIgG Have Role in Immunopathology of Diabetes Type 2.
Islam S, Mir AR, Raghav A, Khan F, Alam K, Ali A, Uddin M.
PLoS One. 2017 Jan 3;12(1):e0169099. DOI: 10.1371/journal.pone.0169099.

11. Scanning Electron Microscopic Analysis of Glycated Histone H2B.
Mir AR*.
Curr Trends Biomedical Eng & Biosci. 2017; 4(2): CTBEB.MS.ID.5555631. DOI:
10.19080/CTBEB.2017.04.5555631

12. Amorphous aggregate adducts of linker histone H1 turn highly immunologic in the cancers of
the esophagus, stomach, gall bladder, and ovary.
Mir AR, Moinuddin, Habib S.
Int J Biol Macromol. 2017 Mar;96:507-517. doi: 10.1016/j.ijbiomac.2016.12.060.

13. Identification of Genes Coding Aminoglycoside Modifying Enzymes in E. coli of UTI
Patients in India.
Mir AR, Bashir Y, Dar FA, Sekhar M.
ScientificWorldJournal. 2016;2016:1875865. DOI: 10.1155/2016/1875865.

14. Neo-epitopes on methylglyoxal modified human serum albumin leads to the aggressive autoimmune response in diabetes.
Jyoti, Mir AR, Habib S, Siddiqui SS, Ali A, Moinuddin.
Int J Biol Macromol. 2016 May;86:799-809. doi: 10.1016/j.ijbiomac.2016.02.019.

15. Immunochemical studies on HNE-modified HSA: Anti-HNE-HSA antibodies as a probe for HNE damaged albumin in SLE.
Khan F, Moinuddin, Mir AR, Islam S, Alam K, Ali A.
Int J Biol Macromol. 2016 May;86:145-54. doi: 10.1016/j.ijbiomac.2016.01.053.

16. Circulating autoantibodies in cancer patients have high specificity for glycoxidation modified histone H2A.
Mir AR, Moinuddin, Islam S.
Clin Chim Acta. 2016 Jan 30;453:48-55. doi: 10.1016/j.cca.2015.12.004.

17. Histone glycoxidation and its role in Cancer autoimmunity.
Mir AR*, Moinuddin.
Clinical & Cellular Immunology. 2016; 7 (5)

18. Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer.
Mir AR, Moinuddin, Habib S, Khan F, Alam K, Ali A.
Glycobiology (Oxford). 2016 Feb;26(2):129-41. doi: 10.1093/glycol/cwv082.

19. Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer.
Mir AR, Uddin M, Khan F, Alam K, Ali A.
PLoS One. 2015 Aug 28;10(8):e0136197. DOI: 10.1371/journal.pone.0136197.

20. Glycoxidation of histone proteins in autoimmune disorders. Review
Mir AR, Moinuddin.
Clin Chim Acta. 2015 Oct 23;450:25-30. doi: 10.1016/j.cca.2015.07.029.

21. Histone protein glycation and Diabetes.
Mir AR*, Bashir Yasir.
Journal of Diabetes Research and Therapy. 2015 1(3). doi: 10.16966/2380-5544.109

22. Methylglyoxal mediated conformational changes in histone H2A-generation of
carboxymethylated advanced glycation end products.
Mir AR, uddin M, Alam K, Ali A.
Int J Biol Macromol. 2014 Aug;69:260-6. doi: 10.1016/j.ijbiomac.2014.05.057.

23. Peroxynitrite modified DNA presents better epitopes for anti-DNA autoantibodies in diabetes type 1 patient.
Tripathi P, Moinuddin, Dixit K, Mir AR, Habib S, Alam K, Ali A.
Cell Immunol. 2014 Jul;290(1):30-8. doi: 10.1016/j.cellimm.2014.04.012.

24. Role of early glycation Amadori products of lysine-rich proteins in the production of autoantibodies in diabetes type 2 patients.
Ansari NA, Moinuddin, Mir AR, Habib S, Alam K, Ali A, Khan RH.
Cell Biochem Biophys. 2014 Nov;70(2):857-65. doi: 10.1007/s12013-014-9991-7.

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